Ligand Id: 3312
Ligand name L-leucine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 63.32
Molecular weight 131.09
XLogP -1.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands
Transporters
Transporter DB page EC number Reaction Reference
L-type amino acid transporter 3 View in GRAC
L-type amino acid transporter 4 View in GRAC
Alanine/serine/cysteine transporter 2 View in GRAC
B0AT1 View in GRAC 5
SNAT2 View in GRAC 2
B0AT2 View in GRAC 5
NTT4 View in GRAC 4
SNAT4 View in GRAC 3
ATB0,+ View in GRAC 1
B0AT3 View in GRAC 6

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Rank order of potency at human receptors (unless otherwise stated)
Description Rank order of potency Reference
Endogenous substrates at Alanine/serine/cysteine transporter 2 L-alanine = L-serine = L-cysteine (low Vmax) = L-threonine = L-glutamine = L-asparagine >> L-methionine ≅ glycine ≅ L-leucine > L-valine > L-glutamic acid (enhanced at low pH)
Endogenous substrates at ATB0,+ L-isoleucine > L-leucine, L-methionine > L-phenylalanine > L-tryptophan > L-valine > L-serine 1
Endogenous substrates at B0AT1 L-leucine, L-methionine, L-isoleucine, L-valine > L-asparagine, L-phenylalanine, L-alanine, L-serine > L-threonine, glycine, L-proline 5
Endogenous substrates at B0AT2 L-proline > L-alanine, L-valine, L-methionine, L-leucine > L-isoleucine, L-threonine, L-asparagine, L-serine, L-phenylalanine > glycine 5
Endogenous substrates at B0AT3 L-alanine, glycine > L-methionine, L-phenylalanine, L-leucine, L-histidine, L-glutamine 6
Endogenous substrates at NTT4 L-leucine, L-methionine, L-proline > L-cysteine, L-alanine, L-glutamine, L-serine > L-histidine, glycine 4
Substrates at SNAT2 L-alanine, L-methionine > L-asparagine, L-glutamine, L-serine, L-proline, glycine > L-threonine, L-leucine, L-phenylalanine 2
Substrates at SNAT4 L-histidine > L-arginine, L-alanine, L-asparagine, L-lysine > glycine, L-glutamine, L-serine, L-proline, L-leucine, L-phenylalanine 3

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org