AM251

Ligand id: 3317

Name: AM251

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 50.16
Molecular weight 554.01
XLogP 5.88
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CB1 receptor Rn Antagonist Antagonist 8.1 pKi - 3
pKi 8.1 (Ki 7.94x10-9 M) [3]
GPR55 Hs Agonist Agonist 5.0 – 7.4 pEC50 - 1-2,6
pEC50 5.0 – 7.4 (EC50 9.6x10-6 – 3.9x10-8 M) [1-2,6]
GPR18 Hs Agonist Partial agonist 4.0 pEC50 - 4
pEC50 4.0 (EC50 9.64x10-5 M) [4]
Ligand mentioned in the following text fields