Synonyms: 21-deoxycortisone
Compound class:
Metabolite or derivative
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Natural/Endogenous Targets | ||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Rank order of potency at Glucocorticoid receptor | cortisol, corticosterone >> aldosterone, deoxycortisone | 1 |
Targets where the ligand is described in the comment field | |
Target | Comment |
CYP11B1 | Converts deoxycortisone and 11-deoxycortisol to cortisone and cortisol, respectively. Loss-of-function mutations are associated with familial adrenal hyperplasia and hypertension. |
CYP21A2 | Converts progesterone and 17α-hydroxyprogesterone to deoxycortisone and 11-deoxycortisol, respectively |