gallamine

Ligand id: 356

Name: gallamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 21
Topological polar surface area 27.69
Molecular weight 510.46
XLogP 4.26
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Gallamine is a negative allosteric modulator of the M2 muscarinic acetylcholine receptor.
Selectivity at GPCRs
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
M2 receptor Hs Allosteric modulator Negative 5.9 – 6.3 pKd - 1,3
pKd 5.9 – 6.3 [1,3]
M2 receptor Hs Allosteric modulator Negative 5.8 – 7.6 pKi - 2,4
pKi 5.8 – 7.6 [2,4]
M2 receptor Rn Allosteric modulator Negative 5.6 pKi - 2
pKi 5.6 [2]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
nicotinic acetylcholine receptor α1 subunit Hs Channel blocker - ~6.0 pIC50 -
pIC50 ~6.0 (IC50 ~1x10-6 M) (α1)2β1γδ and (α1)2β1δε
Ligand mentioned in the following text fields