imipramine

Ligand id: 357

Name: imipramine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 6.48
Molecular weight 280.19
XLogP 5.24
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
M2 receptor Hs Antagonist Antagonist 6.9 pKi - 3
pKi 6.9 [3]
Selectivity at ion channels
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
Kir3.4 Mm Channel blocker Antagonist 4.5 pEC50 - 2
pEC50 4.5 [2]
Voltage: -70.0 mV
Kv10.1 Hs Channel blocker - 5.7 pIC50 - 1
pIC50 5.7 [1]
Kir3.2 Mm Channel blocker Antagonist 4.3 pIC50 - 2
pIC50 4.3 [2]
Voltage: -70.0 mV
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
NET Hs Inhibitor Inhibition 7.8 pKi -
pKi 7.8 (Ki 1.6x10-8 M)
SERT Hs Inhibitor Inhibition 7.7 pKi - 4
pKi 7.7 (Ki 2.03x10-8 M) [4]
Description: Displacement of [3H]citalopram from hSERT.