oxybutynin

Ligand id: 359

Name: oxybutynin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: oxybutynin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 49.77
Molecular weight 357.23
XLogP 5.37
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
M3 receptor Antagonist Antagonist 8.8 – 8.9 pKi - 1-2,4
pKi 8.8 – 8.9 [1-2,4]
M4 receptor Antagonist Antagonist 8.7 pKi - 4
pKi 8.7 [4]
M1 receptor Antagonist Antagonist 8.6 pKi - 1-2,4
pKi 8.6 (Ki 2.4x10-9 M) [1-2,4]
M2 receptor Antagonist Inverse agonist 7.9 pKi - 1
pKi 7.9 (Ki 1.175x10-8 M) [1]
M2 receptor Antagonist Antagonist 7.7 – 8.1 pKi - 2,4
pKi 7.7 – 8.1 [2,4]
M5 receptor Antagonist Antagonist 7.9 pKi - 4
pKi 7.9 [4]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
M1 receptor Antagonist Antagonist 8.2 pKi - 3
pKi 8.2 [3]