ACTH

Ligand id: 3633

Name: ACTH

Species: Human

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View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Although we have recorded affinity data for ACTH at melanocortin receptors 1, 3, 4 and 5, affinity data for the human melanocortin receptor 2, the peptide's primary target, is lacking. As a peptide mimetic of ACTH we would expect corticotropin to have similar affinities to the endogenous peptide.
Natural/Endogenous Targets
Target
MC1 receptor
MC2 receptor
MC3 receptor
MC4 receptor
MC5 receptor
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
MC1 receptor Agonist Agonist 8.6 pKi - 1
pKi 8.6 (Ki 2.5x10-9 M) [1]
MC3 receptor Agonist Agonist 7.1 pKi - 1
pKi 7.1 (Ki 8.69x10-8 M) [1]
MC4 receptor Agonist Agonist 6.2 pKi - 2
pKi 6.2 (Ki 6.93x10-7 M) [2]
MC5 receptor Agonist Agonist <5.0 pKi - 1
pKi <5.0 (Ki >1x10-5 M) [1]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields