ACTH

Ligand id: 3633

Name: ACTH

Species: Human

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Structure and Physico-chemical Properties

2D Structure

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Although we have recorded affinity data for ACTH at melanocortin receptors 1, 3, 4 and 5, affinity data for the human melanocortin receptor 2, the peptide's primary target, is lacking. As a peptide mimetic of ACTH we would expect corticotropin to have similar affinities to the endogenous peptide.
Natural/Endogenous Targets
Target
MC1 receptor
MC2 receptor
MC3 receptor
MC4 receptor
MC5 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
MC1 receptor Hs Agonist Agonist 8.6 pKi - 1
pKi 8.6 (Ki 2.5x10-9 M) [1]
MC3 receptor Hs Agonist Agonist 7.1 pKi - 1
pKi 7.1 (Ki 8.69x10-8 M) [1]
MC4 receptor Hs Agonist Agonist 6.2 pKi - 2
pKi 6.2 (Ki 6.93x10-7 M) [2]
MC5 receptor Hs Agonist Agonist <5.0 pKi - 1
pKi <5.0 (Ki >1x10-5 M) [1]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
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