cabergoline

Ligand id: 37

Name: cabergoline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 67.92
Molecular weight 451.29
XLogP 3.04
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
D2 receptor Agonist Partial agonist 9.0 – 9.2 pKi - 1
pKi 9.0 – 9.2 [1]
D3 receptor Agonist Partial agonist 9.1 pKi - 1
pKi 9.1 [1]
5-HT2B receptor Agonist Full agonist 8.9 pKi - 1
pKi 8.9 [1]
5-HT2A receptor Agonist Full agonist 8.2 pKi - 1
pKi 8.2 [1]
5-HT1D receptor Agonist Partial agonist 8.1 pKi - 1
pKi 8.1 [1]
α2A-adrenoceptor Antagonist Antagonist 7.9 pKi - 1
pKi 7.9 [1]
5-HT1A receptor Agonist Full agonist 7.7 pKi - 1
pKi 7.7 [1]
α2C-adrenoceptor Antagonist Antagonist 7.7 pKi - 1
pKi 7.7 [1]
D5 receptor Agonist Full agonist 7.7 pKi - 1
pKi 7.7 [1]
D4 receptor Agonist Partial agonist 7.3 pKi - 1
pKi 7.3 [1]
α2B-adrenoceptor Antagonist Antagonist 7.1 pKi - 1
pKi 7.1 [1]
D1 receptor Agonist Full agonist 6.7 pKi - 1
pKi 6.7 [1]
α1A-adrenoceptor Antagonist Antagonist 6.5 pKi - 1
pKi 6.5 [1]
5-HT1B receptor Agonist Full agonist 6.3 pKi - 1
pKi 6.3 [1]
5-HT2C receptor Agonist Full agonist 6.2 pKi - 1
pKi 6.2 [1]
Ligand mentioned in the following text fields