cyclopentyladenosine

Ligand id: 380

Name: cyclopentyladenosine

Abbreviated name: CPA

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 125.55
Molecular weight 335.16
XLogP -0.16
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
A1 receptor Hs Agonist Full agonist 6.5 – 9.4 pKi - 1-6,10
pKi 6.5 – 9.4 [1-6,10]
A3 receptor Hs Agonist Full agonist 7.0 – 7.4 pKi - 3,5,7,11
pKi 7.0 – 7.4 [3,5,7,11]
A2A receptor Hs Agonist Full agonist 6.1 pKi - 3,5,7
pKi 6.1 [3,5,7]
A2A receptor Rn Agonist Agonist 6.0 pKi - 8
pKi 6.0 (Ki 9.5x10-7 M) [8]
A2B receptor Hs Agonist Full agonist 4.5 – 4.7 pKi - 5,9
pKi 4.5 – 4.7 [5,9]