mecamylamine

Ligand id: 3990

Name: mecamylamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 12.03
Molecular weight 167.17
XLogP 2.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
nicotinic acetylcholine receptor α4 subunit Channel blocker - 5.3 – 6.5 pIC50 -
pIC50 5.3 – 6.5 (IC50 4.9x10-6 – 3.3x10-7 M) α4β4
pIC50 5.4 – 5.4 (IC50 4.1x10-6 – 3.6x10-6 M) α4β2
nicotinic acetylcholine receptor α1 subunit Channel blocker - ~5.8 pIC50 -
pIC50 ~5.8 (IC50 ~1.5x10-6 M) (α1)2β1δε
nicotinic acetylcholine receptor α3 subunit Channel blocker - 5.1 – 6.4 pIC50 -
pIC50 6.4 (IC50 3.9x10-7 M) α3β4
pIC50 5.1 (IC50 7.6x10-6 M) α3β2
nicotinic acetylcholine receptor α6 subunit Channel blocker - 5.0 pIC50 -
pIC50 5.0 (IC50 1.1x10-5 M) α6/α3β2β3 chimera
nicotinic acetylcholine receptor α7 subunit Channel blocker - 4.8 pIC50 -
pIC50 4.8 (IC50 1.56x10-5 M) (α7)5
nicotinic acetylcholine receptor α2 subunit Channel blocker - - - -