Ligand Id: 4046
Ligand name NF546

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 23
Hydrogen bond donors 10
Rotatable bonds 28
Topological polar surface area 382.89
Molecular weight 1180.13
XLogP 4.53
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Selectivity at human targets (unless otherwise stated)
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
P2Y11 receptor Agonist Full agonist 6.27 pEC50 - 1

Selectivity data from IUPHAR-DB

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
P2Y11 receptor Agonist Full agonist 6.27 pEC50 - 1

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org