amantidine

Ligand id: 4128

Name: amantidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 26.02
Molecular weight 151.14
XLogP 2.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
GluN2C Channel blocker - 4.7 pIC50 - 1
pIC50 4.7 (IC50 2.25x10-5 M) GluN2C = GluN2D ≥ GluN2B ≥ GluN2A [1]
Description: Measured vs. exogenously expressed zeta1/epsilon3 (GRIN1/GRIN2C) subunits, at pH 6.9
GluN2A Channel blocker - - - -
GluN2C = GluN2D ≥ GluN2B ≥ GluN2A
GluN2B Channel blocker - - - -
GluN2C = GluN2D ≥ GluN2B ≥ GluN2A
GluN2D Channel blocker - - - -
GluN2C = GluN2D ≥ GluN2B ≥ GluN2A