View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)
Selectivity at Human ion channels |
Key to terms and symbols
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Click column headers to sort
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GluA1
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Allosteric modulator |
Positive |
- |
- |
- |
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GluA2
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Allosteric modulator |
Positive |
- |
- |
- |
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GluA3
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Allosteric modulator |
Positive |
- |
- |
- |
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GluA4
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Allosteric modulator |
Positive |
- |
- |
- |
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Targets where the ligand is described in the comment field |
Target |
Comment |
GluA2
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Piracetam and aniracetam are examples of pyrrolidinones. Cyclothiazide, S18986, and IDRA-21 are examples of benzothiadiazides. CX516 and CX546 are examples of benzylpiperidines. LY392098, LY404187 and LY503430 are examples of biarylpropylsulfonamides. Also blocked by intracellular polyamines.
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GluA1
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Piracetam and aniracetam are examples of pyrrolidinones. Cyclothiazide, S18986, and IDRA-21 are examples of benzothiadiazides. CX516 and CX546 are examples of benzylpiperidines. LY392098, LY404187 and LY503430 are examples of biarylpropylsulfonamides. Also blocked by intracellular polyamines.
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GluA4
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Piracetam and aniracetam are examples of pyrrolidinones. Cyclothiazide, S18986, and IDRA-21 are examples of benzothiadiazides. CX516 and CX546 are examples of benzylpiperidines. LY392098, LY404187 and LY503430 are examples of biarylpropylsulfonamides. Also blocked by intracellular polyamines
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GluA3
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Piracetam and aniracetam are examples of pyrrolidinones. Cyclothiazide, S18986, and IDRA-21 are examples of benzothiadiazides. CX516 and CX546 are examples of benzylpiperidines. LY392098, LY404187 and LY503430 are examples of biarylpropylsulfonamides. Also blocked by intracellular polyamines
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