benzamil

Ligand id: 4145

Name: benzamil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 145.3
Molecular weight 319.09
XLogP 1.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
ENaCαβγ Hs Channel blocker - ~8.0 pIC50 -
pIC50 ~8.0 (IC50 ~1x10-8 M)
TRPP2 Hs Channel blocker - 6.0 pIC50 -
pIC50 6.0 (IC50 1.1x10-6 M)
ASIC1 Hs Channel blocker - 5.0 pIC50 -
pIC50 5.0 (IC50 1x10-5 M) ASIC1a