cannabidiol

Ligand id: 4150

Name: cannabidiol

Abbreviated name: CBD

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 40.46
Molecular weight 314.22
XLogP 6.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
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Target Type Action Affinity Units Concentration range (M) Reference
GPR18 Agonist Partial agonist 4.3 pEC50 - 4
pEC50 4.3 (EC50 5.11x10-5 M) [4]
GPR55 Antagonist Antagonist 6.3 – 6.5 pIC50 - 5,7
pIC50 6.3 – 6.5 (IC50 4.45x10-7 – 3.5x10-7 M) [5,7]
CB1 receptor Allosteric modulator Negative - - - 3
[3]
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV2 Activator Activation 4.5 pEC50 - 6
pEC50 4.5 (EC50 3.17x10-5 M) [6]
TRPM8 Channel blocker - - - -
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV2 Activator Activation 5.4 pEC50 - 6
pEC50 5.4 (EC50 3.7x10-6 M) [6]
TRPV3 Activator Activation 5.4 pEC50 - 2
pEC50 5.4 (EC50 3.7x10-6 M) [2]
Description: Calcium imaging
Targets where the ligand is described in the comment field
Target Comment
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