cannabidiol

Ligand id: 4150

Name: cannabidiol

Abbreviated name: CBD

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 40.46
Molecular weight 314.22
XLogP 6.34
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
GPR18 Hs Agonist Partial agonist 4.3 pEC50 - 4
pEC50 4.3 (EC50 5.11x10-5 M) [4]
GPR55 Hs Antagonist Antagonist 6.3 – 6.5 pIC50 - 5,7
pIC50 6.3 – 6.5 (IC50 4.45x10-7 – 3.5x10-7 M) [5,7]
CB1 receptor Hs Allosteric modulator Negative - - - 3
[3]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRPV2 Rn Activator Activation 5.4 pEC50 - 6
pEC50 5.4 (EC50 3.7x10-6 M) [6]
TRPV3 Rn Activator Activation 5.4 pEC50 - 2
pEC50 5.4 (EC50 3.7x10-6 M) [2]
Description: Calcium imaging
TRPV2 Hs Activator Activation 4.5 pEC50 - 6
pEC50 4.5 (EC50 3.17x10-5 M) [6]
TRPM8 Hs Channel blocker - - - -
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields