flunitrazepam

Ligand id: 4193

Name: flunitrazepam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 75.81
Molecular weight 313.09
XLogP 3.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
GABAA receptor α1 subunit Allosteric modulator Positive 8.3 pKi - 1
pKi 8.3 (Ki 5.2x10-9 M) [Binds to: benzodiazepine site] [1]
Description: Assay using recombinant GABAA channels with subunit composition; α1β3γ2.
GABAA receptor α2 subunit Allosteric modulator Positive 8.3 pKi - 1
pKi 8.3 (Ki 5.2x10-9 M) [Binds to: benzodiazepine site] [1]
Description: Assay using recombinant GABAA channels with subunit composition; α2β1γ2.
GABAA receptor α5 subunit Allosteric modulator Positive 8.3 pKi - 1
pKi 8.3 (Ki 5.5x10-9 M) [Binds to: benzodiazepine site] [1]
Description: Assay using recombinant GABAA channels with subunit composition; α5β1γ2.
GABAA receptor α3 subunit Allosteric modulator Positive 7.8 pKi - 1
pKi 7.8 (Ki 1.57x10-8 M) [Binds to: benzodiazepine site] [1]
Description: Assay using recombinant GABAA channels with subunit composition; α3β1γ2.
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields