flurbiprofen

Ligand id: 4194

Name: flurbiprofen

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 37.3
Molecular weight 244.09
XLogP 5.51
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
COX-2 Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1x10-8 M) [1]
COX-1 Inhibitor Inhibition 7.1 pIC50 - 3
pIC50 7.1 (IC50 7.5x10-8 M) [3]
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
ASIC1 Channel blocker - 3.5 pIC50 - 2
pIC50 3.5 (IC50 3.5x10-4 M) ASIC1a [2]