isoguvacine

Ligand id: 4226

Name: isoguvacine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 49.33
Molecular weight 127.06
XLogP -0.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GABAA receptor α1 subunit Hs Agonist Full agonist - - -
[Binds to: GABA site]
GABAA receptor α2 subunit Hs Agonist Full agonist - - -
[Binds to: GABA site]
GABAA receptor α3 subunit Hs Agonist Full agonist - - -
[Binds to: GABA site]
GABAA receptor α4 subunit Hs Agonist Full agonist - - -
[Binds to: GABA site]
GABAA receptor α5 subunit Hs Agonist Full agonist - - -
[Binds to: GABA site]
GABAA receptor α6 subunit Hs Agonist Full agonist - - -
[Binds to: GABA site]
GABAA receptor ρ1 subunit Hs Agonist Partial agonist - - -
[Binds to: GABA site]
GABAA receptor ρ2 subunit Hs Agonist Partial agonist - - -
[Binds to: GABA site]
GABAA receptor ρ3 subunit Hs Agonist Partial agonist - - -
[Binds to: GABA site]