KN62

Ligand id: 4235

Name: KN62

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 0
Rotatable bonds 11
Topological polar surface area 146.84
Molecular weight 721.2
XLogP 4.48
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
P2X7 Hs Allosteric modulator Negative - - - 2-3
[2-3]
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Calmodulin-dependent kinase II Hs Inhibitor Inhibition 6.1 pIC50 - 4
pIC50 6.1 (IC50 9x10-7 M) [4]
Ligand mentioned in the following text fields