Ligand Id: 4271
Ligand name NS004

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 52.57
Molecular weight 328.02
XLogP 3.94
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands

Selectivity data from the Guide to Receptors and Channels (GRAC), 5th Edition.

Selectivity at human targets (unless otherwise stated)
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
CFTR Activator Potentiation - - -
KCa1.1 Activator - - - -
KCa4.1 Activator - - - -
KCa4.2 Activator - - - -
KCa5.1 Activator - - - -
Receptors where the ligand is described in the comment field
Receptor Comment
CFTR UCCF-339, UCCF-029, apigenin and genistein are examples of flavones. UCCF-853 and NS004 are examples of benzimidazolones. CBIQ is an example of a benzoquinoline. felodipine and nimodipine are examples of 1,4-dihydropyridines. phenylglycine-01 is an example of a phenylglycine. SF-01 is an example of a sulfonamide. Malonic acid hydrazide conjugates are also CFTR channel blockers (see Verkman and Galietta, 2009 [1])

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
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