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Compound class:
Endogenous peptide in human, mouse or rat
Comment: Thrombin is a serine protease that acts as an agonist at the protease-activated GPCR family. Active thrombin is a complex between thrombin light chain and thrombin heavy chain. The chains are linked by a disulphide bond between cysteine residues at position 9 of the light chain and 118 of the heavy chain.
Species: Human
This ligand is also described as a target entry: coagulation factor II, thrombin |
| Natural/Endogenous Targets | ||||
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| Additional information and targets (data relate to human unless otherwise stated) | ||
| Description | Data | Reference |
| Agonist proteases at PAR1 | thrombin (F2, P00734), activated protein C (PROC, P04070), matrix metalloproteinase 1 (MMP1, P45452), matrix metalloproteinase 13 (MMP13, P45452) | 1 |
| Agonist proteases at PAR3 | thrombin (F2, P00734) | |
| Agonist proteases at PAR4 | thrombin (F2, P00734), trypsin, cathepsin G (CTSG, P08311) | |
| Ligand mentioned in the following text fields |
| Proteinase-activated receptors comments |
