isradipine

Ligand id: 4488

Name: isradipine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 103.55
Molecular weight 371.15
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Due to the complex nature of this drug's MMOA, and the paucity of (human) affinity data, we do not tag a primary drug target.
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Cav1.4 Gating inhibitor - - - 1x10-6 3
Conc range: 1x10-6 M [3]
Voltage: -90.0 – -50.0 mV
Cav1.3 Gating inhibitor - - - 3x10-8 - 3x10-7 2
Conc range: 3x10-8 - 3x10-7 M [2]
Voltage: -90.0 – -50.0 mV
Cav1.3 Gating inhibitor - 9.3 pIC50 - 5
pIC50 9.3 (IC50 5.1x10-10 M) [5]
Description: Recombinant Cav1.3 calcium channel complexes expressed in tsA201-cells
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Cav1.2 Gating inhibitor - 7.5 pIC50 - 4
pIC50 7.5 [4]
Voltage: -80.0 mV
Cav1.4 Gating inhibitor - 6.7 pIC50 - 1
pIC50 6.7 [1]
Voltage: -80.0 mV