γ-hydroxybutyric acid

Ligand id: 4711

Name: γ-hydroxybutyric acid

Abbreviated name: GHB

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 57.53
Molecular weight 104.05
XLogP -0.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have been unable to find publicly available affinity data for this drug at its proposed human targets to substantiate its MMOA. For this reason we have not tagged a primary target for this drug.
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Monocarboxylate transporter 1 4
Vesicular inhibitory amino acid transporter
SMCT1
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
HCA1 receptor Agonist Full agonist 1.8 pEC50 - 1
pEC50 1.8 (EC50 1.53x10-2 M) [1]