sildenafil

Ligand id: 4743

Name: sildenafil

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View more information in the IUPHAR Pharmacology Education Project: sildenafil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 117.18
Molecular weight 475.21
XLogP 1.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
phosphodiesterase 5A Hs Inhibitor Inhibition 8.4 – 9.0 pIC50 - 3-4
pIC50 8.4 – 9.0 (IC50 3.9x10-9 – 1x10-9 M) [3-4]
phosphodiesterase 6C Hs Inhibitor Inhibition 7.4 pIC50 - 4
pIC50 7.4 (IC50 3.92x10-8 M) [4]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
ABCC5 Hs Inhibitor Inhibition 5.9 pKi - 1
pKi 5.9 (Ki 1.2x10-6 M) [1]
OATP1B3 Hs Inhibitor Inhibition 6.1 pIC50 - 2
pIC50 6.1 (IC50 8x10-7 M) [2]
OATP2B1 Hs Inhibitor Inhibition - - - 2
[2]
Description: Inhibition only observed at sildenafil concentrations above those achieved in therapeutic use.
Ligand mentioned in the following text fields