sildenafil

Ligand id: 4743

Name: sildenafil

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View more information in the IUPHAR Pharmacology Education Project: sildenafil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 117.18
Molecular weight 475.21
XLogP 1.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
phosphodiesterase 5A Inhibitor Inhibition 8.4 – 9.0 pIC50 - 3-4
pIC50 8.4 – 9.0 (IC50 3.9x10-9 – 1x10-9 M) [3-4]
phosphodiesterase 6C Inhibitor Inhibition 7.4 pIC50 - 4
pIC50 7.4 (IC50 3.92x10-8 M) [4]
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
ABCC5 Inhibitor Inhibition 5.9 pKi - 1
pKi 5.9 (Ki 1.2x10-6 M) [1]
OATP1B3 Inhibitor Inhibition 6.1 pIC50 - 2
pIC50 6.1 (IC50 8x10-7 M) [2]
OATP2B1 Inhibitor Inhibition - - - 2
[2]
Description: Inhibition only observed at sildenafil concentrations above those achieved in therapeutic use.
Ligand mentioned in the following text fields