paroxetine

Ligand id: 4790

Name: paroxetine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: paroxetine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 39.72
Molecular weight 329.14
XLogP 4.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
P2X4 Antagonist Antagonist 5.0 – 6.0 pIC50 - 2-3
pIC50 5.0 – 6.0 [2-3]
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
SERT Inhibitor Inhibition 10.1 pKd - 1
pKd 10.1 (Kd 8x10-11 M) [1]
SERT Inhibitor Inhibition 9.6 pKi - 4
pKi 9.6 (Ki 2.5x10-10 M) [4]