fludarabine

Ligand id: 4802

Name: fludarabine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 139.54
Molecular weight 285.09
XLogP -1.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Equilibrative nucleoside transporter 3 1
Sodium/nucleoside cotransporter 2 2
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
ribonucleotide reductase catalytic subunit M1 Inhibitor Inhibition 6.0 pIC50 - 3
pIC50 6.0 (IC50 1x10-6 M) [3]
Description: Inhibition of ADP reduction by ribonucleotide reductase from HeLa cells
ribonucleotide reductase regulatory subunit M2 Inhibitor Inhibition 6.0 pIC50 - 3
pIC50 6.0 (IC50 1x10-6 M) [3]
Description: Inhibition of ADP reduction by ribonucleotide reductase from HeLa cells