Ligand Id: 481
Ligand name NS-49

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 100.8
Molecular weight 248.06
XLogP -0.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands

Selectivity data from IUPHAR-DB

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Receptor Type Action Affinity Units Concentration range (M) Reference
α1A-adrenoceptor Agonist Partial agonist 6.2 pKi - 1
α1D-adrenoceptor Agonist Partial agonist 5.4 pKi - 1
α1B-adrenoceptor Agonist Partial agonist 5.1 pKi - 1

Please note: The activity data given on this ligand page represents selected literature values and may not include all reported data.
For more details please contact: curators@iuphar-db.org