folinic acid

Ligand id: 4816

Name: folinic acid

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 14
Hydrogen bond donors 8
Rotatable bonds 11
Topological polar surface area 215.22
Molecular weight 474.17
XLogP -3.67
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Dihydrofolate reductase is the first enzyme with which folinic acid interacts, and by which it is reduced to the active metabolites tetrahydrofolic acid and methyltetrahydrofolate.
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Reduced folate transporter 1