vigabatrin

Ligand id: 4821

Name: vigabatrin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: vigabatrin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 63.32
Molecular weight 129.08
XLogP 0.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Proton-coupled Amino acid Transporter 1 1,5
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
4-aminobutyrate aminotransferase Hs Inhibitor Irreversible inhibition 3.1 pKi - 2,4
pKi 3.1 (Ki 8.5x10-4 M) [2,4]
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Vesicular inhibitory amino acid transporter Hs Inhibitor Inhibition 2.1 pIC50 - 3
pIC50 2.1 (IC50 7.5x10-3 M) [3]