vigabatrin

Ligand id: 4821

Name: vigabatrin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 63.32
Molecular weight 129.08
XLogP 0.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Proton-coupled Amino acid Transporter 1 1,5
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
4-aminobutyrate aminotransferase Inhibitor Irreversible inhibition 3.1 pKi - 2,4
pKi 3.1 (Ki 8.5x10-4 M) [2,4]
Selectivity at human transporters
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Vesicular inhibitory amino acid transporter Inhibitor Inhibition 2.1 pIC50 - 3
pIC50 2.1 (IC50 7.5x10-3 M) [3]