M-CSF   Click here for help

GtoPdb Ligand ID: 4905

Synonyms: CSF-1 | lanimostim | macrophage-CSF
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: M-CSF (CSF1) controls survival and differentiation of macrophages via activation of the CSF1 receptor (a receptor tyrosine kinase). The biologically active peptide is a homodimer or a heterodimer.
Pharmacological modulators of the CSF1/CSF1R axis, targeting tumour-associated macrophage (TAM) survival, are being developed for various solid tumour and hematological oncology indications as well as for autoimmune diseases.
Species: Human
Natural/Endogenous Targets
Target
colony stimulating factor 1 receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
colony stimulating factor 1 receptor Ligand is endogenous in the given species Hs None - - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
MCS110 Peptide Primary target of this compound Hs Antibody Binding 8.5 – 9.8 pKd - 1
⤷ pKd 8.5 – 9.8 (Kd 3x10-9 – 1.6x10-10 M) [1]