growth arrest specific protein 6   Click here for help

GtoPdb Ligand ID: 4935

Abbreviated name: Gas6
Synonyms: AXL receptor tyrosine kinase ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: GAS6 is the sole ligand for AXL receptor tytrosine kinase. Because of AXL's roles in cancer, fibrosis and viral infection, GAS6 has emerged as an attractive target for drug development.
Species: Human
Bioactivity Comments
GAS6 via AXL activation drives epithelial-mesenchymal transition which is a process employed by many cancers during invasion, metastasis and development of chemoresistance.
Natural/Endogenous Targets
Target
AXL receptor tyrosine kinase
MER proto-oncogene, tyrosine kinase
TYRO3 protein tyrosine kinase
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
AXL receptor tyrosine kinase Ligand is endogenous in the given species Hs None - - - - 1
⤷ [1]
TYRO3 protein tyrosine kinase Ligand is endogenous in the given species Hs None - - - - 1
⤷ [1]
MER proto-oncogene, tyrosine kinase Ligand is endogenous in the given species Hs None - - - - 1
⤷ [1]
Ligand mentioned in the following text fields
Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family overview