gefitinib

Ligand id: 4941

Name: gefitinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 68.74
Molecular weight 446.15
XLogP 3.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
epidermal growth factor receptor Hs Inhibitor Inhibition 9.0 pKd - 2
pKd 9.0 (Kd 1x10-9 M) [2]
epidermal growth factor receptor Hs Inhibitor Inhibition 8.3 pKi - 5
pKi 8.3 (Ki 5.5x10-9 M) [5]
Ligand mentioned in the following text fields