IFN-α2

Ligand id: 4960

Name: IFN-α2

Species: Human

Bioactivity Comments
IFN-α2 binds the IFN-α/β receptor (IFNAR), a dimeric receptor that consists of protein chains encoded by the IFNAR1 and IFNAR2 genes, and induces expression of proteins containing ISRE or GAS transcription elements.
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Interferon-α/β receptor Agonist Agonist - - -
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Affinity Units Concentration range (M) Reference
rontalizumab Hs Antibody Binding 10.7 pKd - 3
pKd 10.7 (Kd 1.8x10-11 M) [3]
sifalimumab Hs Antibody Binding 10.0 pKd - 4
pKd 10.0 (Kd 1x10-10 M) [4]