IFN-β   Click here for help

GtoPdb Ligand ID: 4967

Synonyms: Avonex® (recombinant IFN-beta-1a) | fibroblast interferon | interferon beta
Immunopharmacology Ligand
Comment: IFN-β is a type I IFN. The peptide sequence of the clinically used recombinant protein IFN-beta-1a is identical to that of the endogenous peptide.
Species: Human
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Natural/Endogenous Targets
Target
Interferon-α/β receptor
interferon α/β receptor 1
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
interferon α/β receptor 1 Ligand is endogenous in the given species Hs Agonist Agonist 7.8 pKd - 1
pKd 7.8 (Kd 1.58x10-8 M) [1]
Description: Measured using a surface plasmon resonance (SPR) assay, and recombinant hIFNAR1-extracellular domain (ECD) expressed in insect cells.
Interferon-α/β receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -