IL-18   Click here for help

GtoPdb Ligand ID: 4983

Synonyms: ibocatdekin | interferon-γ-inducing factor | interleukin-1 gamma (IL-1 gamma) | interleukin-18
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-18 is an IL-1 family cytokine. It acts as a pleiotropic pro-inflammatory cytokine, and it is important for host innate and adaptive immune defense against pathogenic infections. Dysregulated IL-18 activity is associated with inflammatory and autoimmune diseases (e.g. rheumatoid arthritis, Crohn's disease, MS and lupus), allergies, and neurological disorders. IL-18 and its signalling partners are protein targets for anti-inflammatory drug development.
Species: Human
Natural/Endogenous Targets
Target
Interleukin-18 receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-18 receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
NSC80734 Small molecule or natural product Hs Antagonist Binding 6.4 pKi - 1
⤷ pKi 6.4 (Ki 4.09x10-7 M) [1]
Description: Ki predicted by virtual docking.
tadekinig alfa Peptide Primary target of this compound Hs Antagonist Binding - - - 4
⤷ [4]
camoteskimab Peptide Hs Antibody Binding - - -
⤷
Ligand mentioned in the following text fields
NOD-like receptor family overview