IL-2   Click here for help

GtoPdb Ligand ID: 4985

Synonyms: aldesleukin | interleukin-2 | Proleukin®
Approved drug Immunopharmacology Ligand
IL-2 is an approved drug (FDA (1992))
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-2 and IL-15 are cytokines that share common biological effects, but also exhibit distinct, and sometimes competing, functions [6]. Recombinant IL-2 is used clinically with the generic name aldesleukin.
Abbas et al. (2018) have written a review of IL-2 biology and the progress that has been made in developing IL-2 therapeutics [1].
Species: Human
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Natural/Endogenous Targets
Target
Interleukin-2 receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-2 receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
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Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
SP-4206 Small molecule or natural product Primary target of this compound Hs None Binding 7.2 pIC50 - 2
⤷ pIC50 7.2 (IC50 6x10-8 M) [2]