[125I]BE-2254

Ligand id: 500

Name: [125I]BE-2254    

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 49.33
Molecular weight 421.05
XLogP 5.38
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
α1A-adrenoceptor Hs Antagonist Antagonist 9.9 pKd - 1-2
pKd 9.9 [1-2]
α1B-adrenoceptor Hs Antagonist Inverse agonist 9.9 pKd - 1-2
pKd 9.9 [1-2]
α1D-adrenoceptor Hs Antagonist Antagonist 9.9 pKd - 2
pKd 9.9 [2]