linaclotide

Ligand id: 5017

Name: linaclotide

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View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
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Target Type Action Affinity Units Concentration range (M) Reference
Guanylyl cyclase-C Agonist Agonist 8.9 pKi - 2-3
pKi 8.9 (Ki 1.24x10-9 M) [2-3]
Description: Competitive-inhibition of [125I]-STa binding to T84 colorectal carcinoma cells
Selectivity at rat catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Guanylyl cyclase-C Agonist Agonist 8.4 pKi - 2
pKi 8.4 (Ki 4.2x10-9 M) [2]
Description: Competitive-inhibition of [125I]-STa binding to rat intestinal mucosa