(-)-noradrenaline

Ligand id: 505

Name: (-)-noradrenaline

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 86.71
Molecular weight 169.07
XLogP -0.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Natural/Endogenous Targets
Target
α1A-adrenoceptor
α1B-adrenoceptor
α1D-adrenoceptor
α2A-adrenoceptor
α2B-adrenoceptor
α2C-adrenoceptor
β1-adrenoceptor
β2-adrenoceptor
β3-adrenoceptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
Monoamine oxidase A
Phenylethanolamine N-methyltransferase
Dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Monoamine oxidase B
Catechol-O-methyltransferase
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Vesicular monoamine transporter 1 1
Vesicular monoamine transporter 2 1
Organic cation transporter 3 12
DAT
NET
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α1D-adrenoceptor Agonist Full agonist 7.4 pKi - 4,9
pKi 7.4 [4,9]
α2A-adrenoceptor Agonist Full agonist 5.6 – 7.4 pKi - 5,7
pKi 5.6 – 7.4 [5,7]
α2C-adrenoceptor Agonist Full agonist 5.7 – 6.8 pKi - 5,7
pKi 5.7 – 6.8 [5,7]
α1B-adrenoceptor Agonist Full agonist 6.2 pKi - 9
pKi 6.2 [9]
α1A-adrenoceptor Agonist Full agonist 5.8 – 6.4 pKi - 4,9,11
pKi 5.8 – 6.4 [4,9,11]
β1-adrenoceptor Agonist Agonist 5.5 – 6.0 pKi - 2-3
pKi 5.5 – 6.0 [2-3]
α2B-adrenoceptor Agonist Partial agonist 5.4 – 6.0 pKi - 5,7
pKi 5.4 – 6.0 [5,7]
β3-adrenoceptor Agonist Full agonist 4.7 – 6.3 pKi - 3,8,10
pKi 4.7 – 6.3 [3,8,10]
β2-adrenoceptor Agonist Agonist 4.6 – 4.8 pKi - 2-3
pKi 4.6 – 4.8 [2-3]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
β3-adrenoceptor Agonist Full agonist 3.8 pKi - 8
pKi 3.8 [8]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α1D-adrenoceptor Agonist Full agonist 6.3 pKi - 6
pKi 6.3 [6]
β3-adrenoceptor Agonist Full agonist 4.2 pKi - 8
pKi 4.2 [8]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
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