RANK ligand   Click here for help

GtoPdb Ligand ID: 5066

Synonyms: receptor activator of nuclear factor κB ligand | osteoclast differentiation factor (ODF) | osteoprotegerin ligand | TNFSF11
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: RANK ligand (TNFSF11) is a member of the tumor necrosis factor (TNF) cytokine family. It can exist in both membrane-bound and soluble forms. It is a key factor for osteoclast differentiation and activation. Osteoprotegerin acts as a decoy receptor for RANK ligand.
Species: Human
Natural/Endogenous Targets
Target
receptor activator of NF-kappa B
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
receptor activator of NF-kappa B Ligand is endogenous in the given species Hs None - - - -
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Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
denosumab Peptide Approved drug Primary target of this compound Hs Antibody Binding >9.6 pIC50 - 1
⤷ pIC50 >9.6 (IC50 <2.3x10-10 M) [1]
narlumosbart Peptide Approved drug Hs Antibody Binding - - -
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Targets where the ligand is described in the comment field
Target Comment
osteoprotegerin Acts as a decoy receptor for RANK ligand (TNFSF11, O14788) and possibly for TRAIL (TNFSF10, P50591).