APRIL   Click here for help

GtoPdb Ligand ID: 5068

Synonyms: A proliferation-inducing ligand | TALL2 | TNF- and APOL-related leukocyte expressed ligand 2 | TNF-related death ligand 1 | TRDL-1 | ZTNF2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: APRIL (also known as tumor necrosis factor ligand superfamily member 13; TNFSF13) is a protein of the TNF superfamily recognized by the cell surface catalytic receptor TACI [9] and other TNF family receptors [3]. Three APRIL isoforms have bee reported [1]. We provide the amino acid sequence for the mature peptide chain (i.e. without the 104 amino acid propeptide leader sequence which is cleaved by furin convertase in the Golgi apparatus prior to secretion [4]).
Species: Human
Natural/Endogenous Targets
Target
B cell maturation antigen
TACI
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
TACI Ligand is endogenous in the given species N/A None - - - -
⤷
B cell maturation antigen Ligand is endogenous in the given species Hs None - - - -
⤷
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
sibeprenlimab Peptide Hs Antibody Binding 12.0 pKd - 5
⤷ pKd 12.0 (Kd 9.5x10-13 M) [5]
Description: Binding affinity determined by surface plasmon resonance (SPR)
zigakibart Peptide Hs Antibody Binding 9.1 pEC50 - 8
⤷ pEC50 9.1 (EC50 7.8x10-10 M) [8]
Description: Binding of VH14_1G.VL15 to human APRIL
telitacicept Peptide Approved drug Hs Fusion protein Binding - - - 7
⤷ [7]