brimonidine

Ligand id: 520

Name: brimonidine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 62.2
Molecular weight 291.01
XLogP 1.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
α2A-adrenoceptor Hs Agonist Full agonist 6.7 – 8.7 pKi - 1-4
pKi 6.7 – 8.7 [1-4]
α2B-adrenoceptor Hs Agonist Partial agonist 6.0 – 8.3 pKi - 1,3-4
pKi 6.0 – 8.3 [1,3-4]
α2C-adrenoceptor Hs Agonist Partial agonist 5.7 – 7.6 pKi - 1-4
pKi 5.7 – 7.6 [1-4]
Ligand mentioned in the following text fields