Ligand id: 5209

Name: letrozole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 78.29
Molecular weight 285.1
XLogP 3.01
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CYP19A1 Hs Inhibitor Inhibition 10.7 pKi - 2
pKi 10.7 (Ki 2x10-11 M) [2]
Targets where the ligand is described in the comment field
Target Comment