milrinone

Ligand id: 5225

Name: milrinone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 65.78
Molecular weight 211.07
XLogP 1.25
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
phosphodiesterase 5A Hs Inhibitor Inhibition 7.3 pIC50 -
pIC50 7.3 (IC50 4.91x10-8 M)
phosphodiesterase 2A Hs Inhibitor Inhibition <6.5 pIC50 - 2
pIC50 <6.5 (IC50 >3x10-7 M) [2]
phosphodiesterase 3A Hs Inhibitor Inhibition 6.3 – 6.4 pIC50 - 1-2
pIC50 6.3 – 6.4 (IC50 4.5x10-7 – 4.4x10-7 M) [1-2]
phosphodiesterase 3B Hs Inhibitor Inhibition 6.0 pIC50 - 2
pIC50 6.0 (IC50 1x10-6 M) [2]