riociguat

Ligand id: 5257

Name: riociguat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 138.07
Molecular weight 422.16
XLogP 2.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
We have been unable to find publicly available bioactivity data for this drug at and sGC subunit to substantiate its MMOA, and have therefore not tagged a primary drug target.
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Guanylyl cyclase, α1β1 Activator Activation - - - 1-2
[1-2]
Guanylyl cyclase, α2β1 Activator Activation - - - 1-2
[1-2]