CGP 12177

Ligand id: 532

Name: CGP 12177

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 82.62
Molecular weight 279.16
XLogP 1.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
β1-adrenoceptor Agonist Partial agonist 9.4 pKi - 4
pKi 9.4 [4]
β2-adrenoceptor Antagonist Antagonist 9.4 pKi - 1,4
pKi 9.4 [1,4]
β1-adrenoceptor Antagonist Antagonist 8.8 – 9.3 pKi - 1,3
pKi 8.8 – 9.3 [1,3]
β3-adrenoceptor Agonist Partial agonist 6.1 – 7.3 pKi - 2,4-6
pKi 6.1 – 7.3 (Ki 7.94x10-7 – 5.01x10-8 M) [2,4-6]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
β3-adrenoceptor Agonist Partial agonist 6.8 pKi - 5
pKi 6.8 [5]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
β3-adrenoceptor Agonist Partial agonist 6.8 pKi - 5
pKi 6.8 [5]
Ligand mentioned in the following text fields