CGP 20712A

Ligand id: 541

Name: CGP 20712A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 12
Topological polar surface area 131.86
Molecular weight 494.18
XLogP 3.06
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
β1-adrenoceptor Antagonist Antagonist 8.5 – 9.2 pKi - 1-3
pKi 8.5 – 9.2 (Ki 3.16x10-9 – 6.3x10-10 M) [1-3]
β3-adrenoceptor Antagonist Antagonist 5.1 – 5.7 pKi - 1-4
pKi 5.1 – 5.7 [1-4]