guanabenz

Ligand id: 5443

Name: guanabenz

Abbreviated name: GBZ

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 76.76
Molecular weight 230.01
XLogP 2.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α2A-adrenoceptor Agonist Agonist 7.4 pIC50 - 1
pIC50 7.4 (IC50 4.1x10-8 M) [1]
α2B-adrenoceptor Agonist Agonist 6.8 pIC50 - 1
pIC50 6.8 (IC50 1.49x10-7 M) [1]
α2C-adrenoceptor Agonist Agonist 6.0 pIC50 - 1
pIC50 6.0 (IC50 1.106x10-6 M) [1]
Ligand mentioned in the following text fields