betaxolol

Ligand id: 549

Name: betaxolol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 50.72
Molecular weight 307.21
XLogP 2.77
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Note that β1 selectivity is not absolute, and some inhibitory effects on β2-adrenoceptors (mainly in the bronchial and vascular musculature) is exhibited at higher doses.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
β1-adrenoceptor Antagonist Antagonist 8.8 pKi - 1
pKi 8.8 [1]
β2-adrenoceptor Antagonist Antagonist 7.2 pKi - 1
pKi 7.2 [1]
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