sulpiride

Ligand id: 5501

Name: sulpiride

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 110.11
Molecular weight 341.14
XLogP 0.28
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Sulpiride is selective for the D2 and D3 dopamine receptors. In comparison this drug has low affinity for the other D2-like receptor, D4 dopamine receptor (Ki 2100nM [1])
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
D2 receptor Antagonist Antagonist 7.2 – 7.9 pKi - 2
pKi 7.2 – 7.9 (Ki 6x10-8 – 1.2x10-8 M) [2]
D3 receptor Antagonist Antagonist 6.8 – 7.8 pKi - 2
pKi 6.8 – 7.8 (Ki 1.42x10-7 – 1.4x10-8 M) [2]
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
carbonic anhydrase 12 Inhibitor Inhibition 8.4 pKi - 4
pKi 8.4 (Ki 3.9x10-9 M) [4]
carbonic anhydrase 1 Inhibitor Inhibition 5.9 pKi - 4
pKi 5.9 (Ki 1.2x10-6 M) [4]
carbonic anhydrase 7 Inhibitor Inhibition 5.4 pKi - 3
pKi 5.4 (Ki 3.63x10-6 M) [3]